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Welcome to the -OMICS page of the Department of Neurophysiology at the Donders Institute for Brain, Cognition and Behaviour. The Cortical Plasticity focus group in the Department, led by Dr. Tansu Celikel, systematically searches for the molecular, cellular and network mechanisms of cortical plasticity as we induce neuroplasticity by controlling the sensory and perceptual experience of mice. High-throughput -OMICS based molecular screening is accompanied by targeted molecular and cellular (in)activation studies to causally link molecules and synapses to circuits and behaviour. This portal is an interactive gateway to the molecular data that we collect.

Featured dataset: The transcriptome and proteome of the mouse barrel cortex in single column and laminae resolution in control animals (with all whiskers intact) and after ~2 week long sensory deprivation. The data acquisition procedures, experimental data (raw and processed), and statistical comparisons could be accessed via the tabs on the header.

Terms of Use If you use the data or the figures provided herein in your publications, please consider citing the following paper(s) where the data originate from:

Transcriptome: Kole et al (2017). Transcriptional mapping of the primary somatosensory cortex upon sensory deprivation.
Proteome: Kole et al (2017). Proteomic landscape of the primary somatosensory cortex upon sensory deprivation.
Sample preparation: Kole and Celikel (preprint). Neocortical microdissection at columnar and laminar resolution for molecular interrogation. bioRxiv.